Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs.
Identifieur interne : 004A26 ( Main/Exploration ); précédent : 004A25; suivant : 004A27Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs.
Auteurs : Stinne Ravn Greisen [Danemark] ; Holger Jon M Ller [Danemark] ; Kristian Stengaard-Pedersen [Danemark] ; Merete Lund Hetland [Danemark] ; Kim H Rslev-Petersen [Danemark] ; Peter Junker [Danemark] ; Mikkel Stergaard [Danemark] ; Malene Hvid [Danemark] ; Bent Deleuran [Danemark]Source :
- Clinical and experimental rheumatology [ 0392-856X ]
English descriptors
- KwdEn :
- Adalimumab, Antibodies, Monoclonal, Humanized (administration & dosage), Antigens, CD (blood), Antigens, Differentiation, Myelomonocytic (blood), Antirheumatic Agents (administration & dosage), Arthritis, Rheumatoid (diagnosis), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (immunology), Arthritis, Rheumatoid (physiopathology), Biomarkers (blood), Disease Progression, Early Diagnosis, Female, Humans, Macrophage Activation (drug effects), Macrophage Activation (immunology), Male, Methotrexate (administration & dosage), Middle Aged, Patient Acuity, Predictive Value of Tests, Receptors, Cell Surface (blood), Receptors, Scavenger (blood), Tumor Necrosis Factor-alpha (blood).
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Methotrexate.
- chemical , blood : Antigens, CD, Antigens, Differentiation, Myelomonocytic, Biomarkers, Receptors, Cell Surface, Receptors, Scavenger, Tumor Necrosis Factor-alpha.
- chemical : Adalimumab.
- diagnosis : Arthritis, Rheumatoid.
- drug effects : Macrophage Activation.
- drug therapy : Arthritis, Rheumatoid.
- immunology : Arthritis, Rheumatoid, Macrophage Activation.
- physiopathology : Arthritis, Rheumatoid.
- Disease Progression, Early Diagnosis, Female, Humans, Male, Middle Aged, Patient Acuity, Predictive Value of Tests.
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease where TNF-α is a central mediator of inflammation, and is cleaved from the cell surface by TACE/ADAM17. This metalloproteinase is also responsible for the release of soluble (s) CD163. Soluble CD163 reflects macrophage activation. In RA, sCD163 has been suggested as a marker of disease activity and progression. Our aim is to investigate sCD163 levels in early RA patients.
PubMed: 25962601
Affiliations:
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and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><affiliation wicri:level="1"><nlm:affiliation>King Christian 10th Hospital for the Rheumatic Diseases, and University of Southern Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>King Christian 10th Hospital for the Rheumatic Diseases, and University of Southern Denmark</wicri:regionArea><wicri:noRegion>and University of Southern Denmark</wicri:noRegion></affiliation></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Odense University Hospital, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Odense University Hospital</wicri:regionArea><wicri:noRegion>Odense University Hospital</wicri:noRegion></affiliation></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedicine, and Department of Clinical Medicine, Aarhus University, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Biomedicine, and Department of Clinical Medicine, Aarhus University</wicri:regionArea><wicri:noRegion>Aarhus University</wicri:noRegion></affiliation></author><author><name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital; and Department of Clinical Medicine, Aarhus University, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital; and Department of Clinical Medicine, Aarhus University</wicri:regionArea><wicri:noRegion>Aarhus University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2015 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:25962601</idno><idno type="pmid">25962601</idno><idno type="wicri:Area/PubMed/Corpus">000080</idno><idno type="wicri:Area/PubMed/Curation">000080</idno><idno type="wicri:Area/PubMed/Checkpoint">000851</idno><idno type="wicri:Area/Ncbi/Merge">000D54</idno><idno type="wicri:Area/Ncbi/Curation">000D54</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D54</idno><idno type="wicri:doubleKey">0392-856X::Greisen S:macrophage:activity:assessed</idno><idno type="wicri:Area/Main/Merge">004C02</idno><idno type="wicri:Area/Main/Curation">004A26</idno><idno type="wicri:Area/Main/Exploration">004A26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs.</title><author><name sortKey="Greisen, Stinne Ravn" sort="Greisen, Stinne Ravn" uniqKey="Greisen S" first="Stinne Ravn" last="Greisen">Stinne Ravn Greisen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedicine, Aarhus University; and Department of Rheumatology, Aarhus University Hospital, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Biomedicine, Aarhus University; and Department of Rheumatology, Aarhus University Hospital</wicri:regionArea><wicri:noRegion>Aarhus University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="M Ller, Holger Jon" sort="M Ller, Holger Jon" uniqKey="M Ller H" first="Holger Jon" last="M Ller">Holger Jon M Ller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry, Aarhus University Hospital, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Aarhus University Hospital</wicri:regionArea><wicri:noRegion>Aarhus University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital</wicri:regionArea><wicri:noRegion>Aarhus University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><affiliation wicri:level="1"><nlm:affiliation>King Christian 10th Hospital for the Rheumatic Diseases, and University of Southern Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>King Christian 10th Hospital for the Rheumatic Diseases, and University of Southern Denmark</wicri:regionArea><wicri:noRegion>and University of Southern Denmark</wicri:noRegion></affiliation></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Odense University Hospital, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Odense University Hospital</wicri:regionArea><wicri:noRegion>Odense University Hospital</wicri:noRegion></affiliation></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedicine, and Department of Clinical Medicine, Aarhus University, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Biomedicine, and Department of Clinical Medicine, Aarhus University</wicri:regionArea><wicri:noRegion>Aarhus University</wicri:noRegion></affiliation></author><author><name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital; and Department of Clinical Medicine, Aarhus University, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital; and Department of Clinical Medicine, Aarhus University</wicri:regionArea><wicri:noRegion>Aarhus University</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical and experimental rheumatology</title><idno type="ISSN">0392-856X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adalimumab</term><term>Antibodies, Monoclonal, Humanized (administration & dosage)</term><term>Antigens, CD (blood)</term><term>Antigens, Differentiation, Myelomonocytic (blood)</term><term>Antirheumatic Agents (administration & dosage)</term><term>Arthritis, Rheumatoid (diagnosis)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Arthritis, Rheumatoid (immunology)</term><term>Arthritis, Rheumatoid (physiopathology)</term><term>Biomarkers (blood)</term><term>Disease Progression</term><term>Early Diagnosis</term><term>Female</term><term>Humans</term><term>Macrophage Activation (drug effects)</term><term>Macrophage Activation (immunology)</term><term>Male</term><term>Methotrexate (administration & dosage)</term><term>Middle Aged</term><term>Patient Acuity</term><term>Predictive Value of Tests</term><term>Receptors, Cell Surface (blood)</term><term>Receptors, Scavenger (blood)</term><term>Tumor Necrosis Factor-alpha (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antirheumatic Agents</term><term>Methotrexate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, CD</term><term>Antigens, Differentiation, Myelomonocytic</term><term>Biomarkers</term><term>Receptors, Cell Surface</term><term>Receptors, Scavenger</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adalimumab</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophage Activation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Macrophage Activation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Progression</term><term>Early Diagnosis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Patient Acuity</term><term>Predictive Value of Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rheumatoid arthritis (RA) is a chronic autoimmune disease where TNF-α is a central mediator of inflammation, and is cleaved from the cell surface by TACE/ADAM17. This metalloproteinase is also responsible for the release of soluble (s) CD163. Soluble CD163 reflects macrophage activation. In RA, sCD163 has been suggested as a marker of disease activity and progression. Our aim is to investigate sCD163 levels in early RA patients.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Greisen, Stinne Ravn" sort="Greisen, Stinne Ravn" uniqKey="Greisen S" first="Stinne Ravn" last="Greisen">Stinne Ravn Greisen</name></noRegion><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name><name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><name sortKey="M Ller, Holger Jon" sort="M Ller, Holger Jon" uniqKey="M Ller H" first="Holger Jon" last="M Ller">Holger Jon M Ller</name><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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